Gen Genome-wide in women with migraine


Scientists from Brigham and Women’s Hospital in Boston say they’ve uncovered a trio of genes tied to these debilitating headaches, including one that is exclusively linked to women, Agence-France Presse reported.

For the study, researchers put together what is called a genome-wide association study that involved more than 23,000 women – including more than 5,000 migraine sufferers.

According to the National Genome Research Institute, this type of study is “an approach that involves rapidly scanning markers across the complete sets of DNA, or genomes, of many people to find genetic variations associated with a particular disease.”

After analyzing all the data, the researchers found variations in three genes that showed up more frequently in women afflicted by migraines.

Studies of twins indicate a 60- to 65-percent genetic influence upon their propensity to develop migraine headaches. Moreover, fluctuating hormone levels indicate a migraine relation: 75 percent of adult patients are women, although migraine affects approximately equal numbers of prepubescent boys and girls; propensity to migraine headache is known to disappear during pregnancy, although in some women migraines may become more frequent during pregnancy.

Migraiin

Migraine meaning skull is a debilitating condition characterized by moderate to severe headaches, and nausea. It is about three times more common in women than in men.

The typical migraine headache is unilateral (affecting one half of the head) and pulsating in nature and lasting from 4 to 72 hours; symptoms include nausea, vomiting, photophobia (increased sensitivity to light), phonophobia (increased sensitivity to sound); the symptoms are generally aggravated by routine activity. Approximately one-third of people who suffer from migraine headaches perceive an aura—unusual visual, olfactory, or other sensory experiences that are a sign that the migraine will soon occur.

Initial treatment is with analgesics for the headache, an antiemetic for the nausea, and the avoidance of triggering conditions. The cause of migraine headache is unknown; the most common theory is a disorder of the serotonergic control system.

source : usatoday.com, wikpedia

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